Quantitative determination of 3-O-methyldopa in DBS by LC-MS/MS technique
- Test objective: The 3-O-methyldopa determination is used as a screening test for L-amino acid decarboxylasedeficiency (AADC deficiency, ORPHA:35708).
- Method of testing: High-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS
- Analysed substances: 3-O-methyldopa (3-OMD)
- Type of test material: Dry blood spot
- Test category: DBS, Metabolomics
3-O-methyldopa (3-OMD) testing from dried blood spot — patient-centric sampling
Masdiag Laboratory offers 3-O-methyldopa (3-OMD) analysis from dried blood spot (DBS) using validated LC-MS/MS methodology. DBS is a patient-centric sampling approach — the patient collects a few drops of capillary blood at home with a simple finger prick, dries the sample on filter paper, and ships it to our laboratory via standard post. No clinic visit. No cold chain. No venipuncture.
This approach is increasingly adopted by supplement companies, nutraceutical brands, health tech platforms and clinical research organisations as a scalable, convenient alternative to conventional blood testing.
Test material: Dried blood spot (DBS), serum, plasma | Method: LC-MS/MS | ISO 15189 compliant | Available for: rare disease clinics · research institutions · paediatric neurology · international partners