Quantitative determination of phenylbutyrate (PBA) metabolites in plasma/serum or urine using the LC-MS/MS technique

Test objective: Assessment of the efficacy of phenylbutyrate supplementation, including Ravicti (phenylbutyrate glycerol)
Method of testing: High-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)
Analysed substances: Phenylbutyric acid (PBA), Phenylacetic acid (PAA), Phenylacetylglutamine (PAGN)
Type of test material: Serum, plasma, urine
Test category: Metabolomics